Not only is knowledge of the behavioral purpose of RGC signals critical for understanding the retinal contributions to vision it can also guide us to the most relevant areas of visual feature space.ĭirection selectivity looming luminance contrast object motion orientation selectivity receptive field. In this article, I review the feature selectivities of mouse RGCs, how they arise, and how they are utilized downstream. Retinal Ganglion Cells (RGCs) are the sole cells through which visual information is transmitted from the eye to the brain. Current maps connecting RGC types to brain areas are rudimentary, as is our understanding of how retinal signals are transformed downstream to guide behavior. Anterograde tracing indicates that RGCs innervate more than 50 areas in the mouse brain. The number of RGCs in linear units at a given test field location was determined by multiplying the antilog of the cell density by the retinal area that. A catalog of the RGC feature set, in turn, is fundamental to understanding visual processing in the brain. RGCs are the output neurons of the retina, transmitting signals along their axons to the brain. RGC cellular characteristics were correlated with functional visual field measurements. To understand the retina, we need to know how retinal circuits give rise to the diverse RGC feature representations. One particular group of RGCs, called melanopsin RGCs, play a critical role in regulating sleep, mood, and pupil constriction, and it is likely that their. 1 The RGC-5 cell line has been widely used since then, reproducing several of the original findings and their retinal ganglion cell phenotype. 4, 5, 16 RGCs are transparent and do not have any particular discriminating optical property. 15 Several experimental studies have indicated that RGC apoptosis occurs in the ganglion cell layer in glaucoma. RGCs extract features of varying complexity some simply signal local differences in brightness (i.e., luminance contrast), whereas others detect specific motion trajectories. Our laboratory previously reported the generation of a retinal ganglion cell 5 (RGC-5) cell line with phenotypic expression of many retinal ganglion cell markers. The human retina contains 1.5 million RGCs, which are not confined to 1 of the 10 distinct retinal layers. Functional, morphological, and transcriptomic surveys have identified more than 40 retinal ganglion cell (RGC) types in mice. 560 Axonal cells (AxCs) conventional fast synapses see Retinal synaptic. Retinal circuits transform the pixel representation of photoreceptors into the feature representations of ganglion cells, whose axons transmit these representations to the brain. growth, 557 guidance, 557558 injury signaling, RGC death, 563564 number.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |